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From the North
Travel I-79 S towards Pittsburgh.
Slight left onto I-279 S (signs for Pittsburgh)
Take exit 1A on the left toward Fort Duquesne Blvd
Keep right at the fork, follow signs for Ft Duquesne Blvd and merge onto Fort Duquesne Blvd
One Gateway Center will be on the right

From the South
Travel I-79 N towards Pittsburgh.
Merge onto I-376 E towards Pittsburgh
Take exit 6C for Fort Duquesne Boulevard
Merge onto Fort Duquesne Blvd
One Gateway Center will be on the right

From the East
Travel I-376 W/US-22 W towards Pittsburgh.
Take exit 70D on the left for Stanwix St
Turn left onto Fort Pitt Blvd
Continue onto Commonwealth Pl
Continue onto Fort Duquesne Blvd
One Gateway Center will be on the right

From the West
Travel US-22 E/US-30 E towards Pittsburgh.
Merge onto I-376 E
Take exit 6C for Fort Duquesne Boulevard
Merge onto Fort Duquesne Blvd
One Gateway Center will be on the right